2-Chlorothiophene → 2-Fluoro-5-nitrobenzoyl chloride

HRID 2292253Notes

Reaction equation

HRID 2292253 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](O)=[O:5].S1C=CC=C1[Cl:19]>>[F:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([Cl:19])=[O:5]

Participants

3

Reactant 2

HCID 72992-ChlorothiopheneHCID 2809972-Fluoro-5-nitrobenzoic acid

Product 1

HCID 109765702-Fluoro-5-nitrobenzoyl chloride

Procedure

A solution of 42 g of 2-fluoro-5-nitro-benzoic acid [prepared by Chim. et Ind. 1970, p. 892] melting at 139°-140° C. and 120 ml of thienyl chloride was refluxed for two hours and was then distilled at 40° C. under a pressure of 30 to 40 mm Hg. The residue was taken up in benzene and the solution was evaporated to dryness to obtain 44 g of 2-fluoro-5-nitro-benzoyl chloride melting at 59°-60° C.

Workup

  1. distillationwas then distilled at 40° C. under a pressure of 30 to 40 mm Hg
  2. customthe solution was evaporated to dryness

Sources & evidence

ORD record
ord-bf1a1504dc3d438db32fad05a64a7964
Source dataset
uspto-grants-1989_01
Patent number
US04801717

Reaction notes

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