Isopropyl iodide → 1-Fluoro-3-isopropoxybenzene

HRID 2292256Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH:9](I)([CH3:11])[CH3:10]>>[F:1][C:2]1[CH:3]=[C:4]([O:8][CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 97433-Fluorophenol

Product 1

HCID 27374601-Fluoro-3-isopropoxybenzene

Procedure

3-fluoro-phenol and isopropyl iodide were reacted to form 3-fluoro-isopropoxy-benzene which was reacted with nitric acid to obtain 2-isopropoxy-4-fluoro-nitro benzene which was reacted as in Example 1 to obtain 0-(4-nitro-3-isopropoxy-phenyl)-hydroxylamine melting at 104° C.

Sources & evidence

ORD record: ord-0b2da674262a47d68e1126f538d093ac
Source dataset: uspto-grants-1989_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04801717

Reaction notes

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