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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2292272Generated: October 30, 2026

p-Fluoronitrobenzene → 2-[(Benzenesulfonyl)methyl]-4-fluoro-1-nitrobenzene

https://huagongshe.com/reaction/2292272

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-FluoronitrobenzeneHCID 9590—
Reactant((Chloromethyl)sulphonyl)benzeneHCID 81625—
SolventDimethyl SulfoxideHCID 679—
Product2-[(Benzenesulfonyl)methyl]-4-fluoro-1-nitrobenzeneHCID 13180796—

Reaction Steps

4-nitro-fluorobenzene and phenylsulfonylmethyl chloride were reacted in dimethylsulfoxide in the presence of potassium tert.-butylate to form 4-nitro-3-(phenylsulfonylmethyl)-fluorobenzene which was reacted with N-hydroxy-phthalimide to form 0-[4-nitro-3-(phenylsulfonylmethyl)-phenoxy]-phthalimide which was reacted to obtain 0-[4-nitro-3-phenylsulfonylmethyl)-phenyl]-hydroxylamine melting at 195°-196° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04801717
Source datasetuspto-grants-1989_01
ORD IDord-f4f8dfd778c44d438da3e3a28d133030
Source noteuspto-grants-1989_01