Acetic Anhydride → HCID 21277452, compound

HRID 2292316Notes

Reaction equation

HRID 2292316 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:11]([CH3:14])([CH3:13])[CH2:10][CH2:9][C:8]([CH3:16])([CH3:15])[C:7]=2[CH:6]=[C:5]([O:17][CH3:18])[C:4]=1/[CH:19]=[CH:20]/[C:21]1[CH:28]=[CH:27][C:24]([CH2:25][OH:26])=[CH:23][CH:22]=1.[C:29](OC(=O)C)(=[O:31])[CH3:30]>N1C=CC=CC=1>[C:29]([O:26][CH2:25][C:24]1[CH:23]=[CH:22][C:21](/[CH:20]=[CH:19]/[C:4]2[C:5]([O:17][CH3:18])=[CH:6][C:7]3[C:8]([CH3:16])([CH3:15])[CH2:9][CH2:10][C:11]([CH3:13])([CH3:14])[C:12]=3[C:3]=2[O:2][CH3:1])=[CH:28][CH:27]=1)(=[O:31])[CH3:30]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 68116919HCID 68116919, compound

Product 1

HCID 21277452HCID 21277452, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1 g (2.7 millimoles) of the benzyl alcohol derivative from Example 27 was dissolved in 5 ml of pyridine, and 1 ml of acetic anhydride was added. The mixture was stirred overnight at room temperature, after which ice/water was added and the resulting solid was filtered off under suction, washed with water, with 0.5N HCl and again with water and dried to give 1 g of the title compound of melting point 73°-74° C.

Workup

  1. filtrationthe resulting solid was filtered off under suction
  2. washwashed with water, with 0.5N HCl and again with water
  3. customdried

Sources & evidence

ORD record
ord-13888cd4a978481986791dbc57af9f13
Source dataset
uspto-grants-1989_01
Patent number
US04801733

Reaction notes

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