Trifluoroacetic acid → HCID 131715833, compound

Participants

Reaction Steps

(S)-[1-[[[[[[3-[(3,4-Dihydroxybenzoyl)amino]-2-oxo-1-imidazolidinyl]carbonyl]amino]sulfonyl]amino]carbonyl]-2-oxo-3-azetidinyl]carbamic acid, phenylmethyl ester (1.4 g) was added to a mixture of 6 ml of trifluoroacetic acid and 1.5 ml of thioanisole. The mixture was stirred overnight at room temperature. The trifluoroacetic acid was removed in vacuo and the residue triturated with ether to yield 1.4 g of crude (S)-N-[[[(3-amino-2-oxo-1-azetidinyl)carbonyl]amino]sulfonyl]-3-[(3,4-dihydroxybenzoyl)amino]-2-oxo-1-imidazolidinecarboxamide, trifluoroacetate salt.

Provenance & Evidence