Trifluoroacetic acid → HCID 131715834, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 12 ml of trifluoroacetic acid and 3 ml of thioanisole was added 2.92 g (4.94 mmol) of (S)-[1-[[[[4-[(3,4-dihydroxybenzoyl)amino]-2,3-dioxo-1-piperazinyl]sulfonyl]amino]carbonyl]-2-oxo-3-azetidinyl]carbamic acid, phenylmethyl ester at 0° C. After stirring overnight at 10° C., 150 ml of ether was added and the resulting precipitate was filtered off, washed with ether and dried in vacuo. For further purification, the salt was triturated two times with dichloromethane; yield: 2.56 g; melting point 206°-210° C.

Provenance & Evidence