Trifluoroacetic acid → HCID 54104709, compound

Participants

Reaction Conditions

Reaction Steps

4 Grams (0.008 mol) of (S)-4,5-dihydroxyl-2-[[[[[2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-azetidinyl]carbonyl]amino]sulfonyl]amino]benzoic acid was added at 10° C. to a stirred mixture of 3.2 ml of thioanisole and 14 ml of trifluoroacetic acid. The mixture was stirred overnight at 10° C., evaporated and treated with ether to yield 4.6 g of crude (S)-2-[[[[(3-amino-2-oxo-1-azetidinyl)carbonyl]amino]sulfonyl]amino]-4,5-dihydroxybenzoic acid.

Provenance & Evidence