Trifluoroacetic acid → HCID 178460210, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 10.83 g (13.6 mmol) of the crude [[[[[(S)-3-[[(Z)-(2-amino-4-thiazolyl)[(2-carboxy-2-methylethoxy)imino]acetyl]amino]-2-oxo-1-azetidinyl]carbonyl]amino]sulfonyl]amino]-3,4-dihydroxybenzeneacetic acid, diphenylmethyl ester in 45 ml of dry dichloromethane at -10° C., a cold solution of 11 ml of anisole in 110 ml of trifluoroacetic acid was added. After being stirred at 0° C. for 10 minutes, the clear solution was evaporated in vacuo at 0°-5° C. and the residue was treated with dry ether. The solid was collected by suction, washed with dry ether, dried in vacuo to give 7.28 g of impure [[[[[(S)-3-[[(Z)-(2-amino-4-thiazolyl)[(2-carboxy-2-methylethoxy)imino]acetyl]amino]-2-oxo-1-azetidinyl]carbonyl]amino]sulfonyl]amino]-3,4-dihydroxybenzeneacetic acid, trifluoroacetate salt.

Provenance & Evidence