Methylhydrazine → HCID 57280465, compound

HRID 2292358Notes

Reaction equation

HRID 2292358 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[OH:13])[C:5](OCC)=[O:6].[CH3:14][NH:15][NH2:16]>>[CH3:14][N:15]([C:5](=[O:6])[C:4]1[CH:10]=[CH:11][C:12]([OH:13])=[C:2]([OH:1])[CH:3]=1)[NH2:16]

Participants

3

Reactant 2

HCID 6061MethylhydrazineHCID 77547Ethyl 3,4-Dihydroxybenzoate

Product 1

HCID 57280465HCID 57280465, compound

Procedure

0.11 g (0.05 mol) of 3,4-dihydroxybenzoic acid, ethyl ester and 106 ml of methylhydrazine (2 mol) were refluxed for 3 days. The reaction mixture was evaporated in vacuo and the oily residue treated with ethanol and evaporated again. This was repeated once more. After retreatment with ethanol, 3,4-dihydroxybenzoic acid, 1-methylhydrazide began to crystallize. The crude product was removed by filtration and recrystallized from ethanol; yield: 3.8 g, melting point 202°-205° C.

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. additionthe oily residue treated with ethanol
  3. customevaporated again
  4. customto crystallize
  5. customThe crude product was removed by filtration
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-c5299031cebb41229891fe775c6129c3
Source dataset
uspto-grants-1989_01
Patent number
US04801705

Reaction notes

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