Trifluoroacetic acid → HCID 131715849, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 10 ml of thioanisole and 40 ml of trifluoroacetic acid was cooled to 0° C., and 8.36 g (20 mmol) of (S)-[1-[[[[(3,4-dihydroxyphenyl)amino]sulfonyl]amino]carbonyl]-2-oxo-3-azetidinyl]carbamic acid, phenylmethyl ester was added. The reaction mixture was stirred overnight at room temperature and the trifluoroacetic acid evaporated in vacuo. The oily residue was triturated with ether and the precipitate filtered off by suction. The crude product was washed with ether, dichloromethane and isopropanol and dried in vacuo; yield: 6.86 g.

Provenance & Evidence