Chlorosulfonyl isocyanate → HCID 86742712, compound

Participants

Reaction Steps

To a suspension of 3.9 g (17.8 mmol) of (S)-(2-oxo-3-azetidinyl)carbamic acid, phenylmethyl ester in 30 ml of ethyl acetate was added 2.5 g (17.8 mmol) of chlorosulfonyl isocyanate. The reaction mixture was stirred for one hour at room temperature and a solution of 7.14 g (17.8 mmol) of 1-[3,4-bis[(trimethylsilyl)oxy]phenyl]-3-(trimethylsilyl)-2-imidazolidinone in 30 ml of ethyl acetate was added dropwise. After stirring overnight at room temperature, the mixture was washed with brine, dried over sodium sulfate and evaporated in vacuo; yield: 8.46 g.

Provenance & Evidence