Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 1-Bromopentane | HCID 8057 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54122132 | HCID 54122132 | — |
Reaction Steps
Alcoholic sodium ethoxide, prepared from sodium (7.8 g, 0.34 mol) in super-dry ethanol (200 cm3) was cooled to ca. 50° C. and diethyl malonate (55 g, 0.34 mol) added slowly with vigorous stirring. 1-Bromopentane (49.5 g, 0.33 mol) was added gradually and the mixture refluxed until neutral to moist litmus (ca. 2 h). The solvent was removed in vacuo and water (200 cm3) added. The aqueous layer was extracted with diethyl ether (2×100 cm3) and the combined ethereal layers were dried (Na2SO4). The solvent was removed in vacuo and the pure product isolated by distillation under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05683623 |
|---|
| Source dataset | uspto-grants-1997_11 |
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| ORD ID | ord-38560d9ccb1c4fca9bb3a269702a9422 |
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| Source note | uspto-grants-1997_11 |
|---|
