HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → 3-(2,3-Dichloro-5-nitrophenylmethyl)-1-methyl-6-trifluoromethyluracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(2,3-Dichloro-5-nitrophenylmethyl)-6-trifluoromethyluracil | HCID 21478104 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-(2,3-Dichloro-5-nitrophenylmethyl)-1-methyl-6-trifluoromethyluracil | HCID 21478127 | 20.8% |
Reaction Steps
By the method of Example 1, Step H, 24.5 grams (0.064 mole) of 3-(2,3-dichloro-5-nitrophenylmethyl)-6-trifluoromethyluracil, 12.07 grams (0.096 mole) of dimethyl sulfate, and 17.64 grams (0.127 mole) of potassium carbonate were reacted in 300 mL of acetone, yielding 5.30 grams of 3-(2,3-dichloro-5-nitrophenylmethyl)-1-methyl-6-trifluoromethyluracil as a bright yellow solid. The NMR spectrum was consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05683966 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-fe5b77b95182491a9ee77c7c9c7deb8d |
| Source note | uspto-grants-1997_11 |