Pyridine → HCID 21478738, compound

Participants

Reaction Steps

To a solution of 9-(n-butyl)-3-oxa-9-azabicyclo-[3.3.1]-nonan-7-one (28 g) in ethanol (150 ml) were added in turn pyridine (18.0 ml) and hydroxylamine hydrochloride (11.9 g) and the mixture was heated under reflux for 40 minutes. To the reaction solution were added water (29 ml) and potassium carbonate (57.9 g), the mixture was stirred for 30 minutes and dried over potassium carbonate. The solvent was distilled off under reduced pressure to give the crude 9-(n-butyl)-3-oxa-9-azabicyclo[3.3.1]nonan-7-one oxime. This product was employed for the sebsequent reaction without any purification.

Provenance & Evidence