HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 9932026, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trisodium Phosphate | HCID 24243 | — |
| Reactant | Sodium Chlorite | HCID 23668197 | — |
| Reactant | HCID 54571409 | HCID 54571409 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | 2-Methyl-2-butene | HCID 10553 | — |
| Product | HCID 9932026 | HCID 9932026 | — |
Reaction Steps
Sodium chlorite is added to a mixture of 17β-(4-fluorobenzoyl)-androsta-3,5-diene-3-carboxaldehyde, sodium phosphate, monobasic monohydrate in 2-methyl-2-butene in THF, H2O, and t-butanol at RT. After 6 h acetic acid was added, then the aqueous layer is extracted with EtOAc, the combined organic extracts are dried (MgSO4), filtered, concentrated, and flash chromatographed to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05683995 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-b2c1cb349a34487c93452157e22a20ca |
| Source note | uspto-grants-1997_11 |