Citric Acid → HCID 86751488, compound

HRID 2292496Notes

Reaction equation

HRID 2292496 reaction equation
[C:1]([OH:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].[CH2:14]([N:16]([CH2:43][CH3:44])[CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25](/[C:28](/[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[C:29](/[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)\[Cl:30])=[CH:24][CH:23]=1)[CH3:15]>C(O)C>[C:1]([OH:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].[CH2:43]([N:16]([CH2:14][CH3:15])[CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25](/[C:28](/[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[C:29](\[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)/[Cl:30])=[CH:24][CH:23]=1)[CH3:44]

Participants

4

Reactant 2

HCID 311Citric Acid2×HCID 86749548HCID 86749548, compound

Product 1

HCID 86751488HCID 86751488, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
4 °C

Procedure

Combine citric acid (164.7 mg, 0.86 mmol) and ethanol (3 mL) and heat until the solid dissolves. Combine (Z)-1-[4-(4-diethylaminobutoxy)phenyl]-1,2-diphenyl-2-chloro-ethylene (372.6 mg, 0.86 mmol) and warm ethanol (3 mL) and add with stirring to the citric acid solution prepared above. Cool to 4° C. and allow to stand for 18 hours. Filter to give the title compound as a solid: mp; 127°-130° C.

Workup

  1. dissolutiondissolves
  2. additionadd
  3. customprepared above
  4. filtrationFilter

Sources & evidence

ORD record
ord-174da0088a034739ab13532f3c79803c
Source dataset
uspto-grants-1997_11
Patent number
US05684004

Reaction notes

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