Norchlorcyclizine → HCID 21478657, compound

Participants

Reaction Conditions

Reaction Steps

Twenty five milliliters of dimethylformamide is added to 2.3 g of the compound of Example 209, 2.6 g of 1-[(4-chlorophenyl)phenylmethyl]piperazine and 2.2g of potassium carbonate and the resulting mixture is stirred at 100° C. for 4 hours. To the mixture, 0.35 g of 1-[(4-chlorophenyl)phenylmethyl]piperazine is added and the resulting mixture is stirred at 100° C. for 2.5 hours. The precipitate is removed by filtration and the filtrate is condensed, followed by purification by silica gel column chromatography (ethyl acetate:methanol=9:1-8:1) to obtain 3.7 g of (210).

Provenance & Evidence