Sodium Hydroxide → HCID 19705068, compound

HRID 2292543Notes

Reaction equation

HRID 2292543 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])=[C:4]([CH3:16])[N:3]=1.[N+:17]([O-])([O-:19])=[O:18].[K+].[OH-].[Na+]>OS(O)(=O)=O>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=[CH:11][C:10]=2[Cl:15])=[C:4]([CH3:16])[N:3]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24434Potassium NitrateHCID 19705069HCID 19705069, compound

Product 1

HCID 19705068HCID 19705068, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a solution of 2,4-diamino-5-(2-chlorophenyl)-6-methyl pyrimidine (11.84 g) (Example 22) in concentrated H2SO4 (100 ml), was added potassium nitrate (5.1 g). After stirring at room temperature for 90 minutes, the solution was poured onto ice and basified with 10N NaOH. The product was extracted with ethyl acetate, bulked, dried (MgSO4) and evaporated, 13.9 g, 236°-240° C.

Workup

  1. extractionThe product was extracted with ethyl acetate
  2. dry with materialdried (MgSO4)
  3. customevaporated
  4. custom13.9 g, 236°-240° C.

Sources & evidence

ORD record
ord-46ab357fa34f4218b9a905fbae8ad83a
Source dataset
uspto-grants-1997_11
Patent number
US05684005

Reaction notes

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