Thiourea → HCID 86751487, compound

Participants

Reaction Steps

Thiourea (0.29 g) and 4,4-difluoro-3-butenyl 4-methyl-benzenesulfonate (see Example 3B) (1 g) were heated together under reflux in ethanol (20 cm3) for 24 hours. The reaction mixture was cooled and the solvent evaporated under reduced pressure to give an oil which slowly crystallised. Trituration with hexane gave (4,4-difluoro-3-butenyl)-thiourea tosylate salt (1.14 g). MH+ (FAB)=167; 1H NMR (DMSO): 2.48(3H,s); 2.46-2.58(2H,m); 3.42(2H,t); 4.66-4.84(1H,m) 7.32(2H,d); 7.68(2H,d); 9.10-9.40(3H, broad)

Provenance & Evidence