Water → HCID 21478844, compound

Participants

Reaction Steps

To a solution of 1-chloro-3-phenyl-propan-2-one (10 g, 59 mmol) in dichloromethane (100 ml) was added benzylpiperazine (12.3 ml, 71 mmol) and triethylamine (8.2 ml, 59 mmol). The yellow solution was stirred overnight at ambient temperature and water was added (50 ml). The organic phase was decanted, washed with brine (50 ml), dried (sodium sulphate) and evaporated. The residue was purified by column chromatography on silica using petroleum ether (60-80) ethyl acetate to afford a yellow oil (2.4 g, 13%). 1H NMR (250 MHz, CDCl3) δ 2.30-2.64 (8H, m), 3.19 (2H, s), 3.51 (2H, s), 3.74 (2H, s), 7.17-7.38 (10H, m).

Provenance & Evidence