Trifluoroacetic acid → HCID 21478957, compound

Participants

Reaction Steps

Combine 5,7-dichloro-4-benzyloxy-2-benzoylquinoline (1.07 g, 2.6 mmol) and trifluoroacetic acid (65 mL) and heat to 70° C. After 4 hours evaporate the reaction mixture in vacuo to give a residue. Recrystallize the residue from acetonitrile to give the title compound; mp, 242°-243° C. Rf =0.33 TLC/silica gel/2% acetone in dichloromethane. Elem. Anal. Calcd. for C16H9Cl2NO2 : C, 60.40; H, 2.85; N, 4.40. Found: C, 60.35; H, 2.89; N, 4.50.

Provenance & Evidence