Dichloromethane → HCID 178466992, compound

Participants

Reaction Steps

Combine 5,7-dichloro-2-acetyl-1,4-dihydroquinol-4-one (0.28 g, 1.1 mmol) and benzenesulfonyl isocyanate (0.16 mL, 1.2 mmol) in acetonitrile (5 mL). Heat at reflux for 3 hours. Add methanol (5 mL) to quench the reaction. Evaporate in vacuo to obtain a residue. Chromatograph the residue on a column of silica gel eluting with dichloromethane to obtain a solid. Recrystallize the solid from ethyl acetate/hexane to give the title compound; mp, 163°-164° C. Rf =0.32 TLC/silica gel/dichloromethane. Elem. Anal. Calcd. for C17H12Cl2 N2O3S: C, 51.65; H, 3.04; N, 7.09.

Provenance & Evidence