Phenylsulphonyl isocyanate → HCID 178452697, compound

HRID 2292632Notes

Reaction equation

HRID 2292632 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]2[C:3]=1[C:4](=O)[CH:5]=[C:6]([C:13](=[O:28])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[NH:7]2.[C:30]1([S:36]([N:39]=C=O)(=[O:38])=[O:37])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>C(#N)C>[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[N:39][S:36]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)(=[O:38])=[O:37])[CH:5]=[C:6]([C:13](=[O:28])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:22])[NH:7]2

Participants

4

Reactant 2

HCID 76096Phenylsulphonyl isocyanateHCID 21478946HCID 21478946, compound

Product 1

HCID 178452697HCID 178452697, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Combine 5,7-dichloro-2-[2-(t-butoxycarbonylamino) benzoyl]-1,4-dihydroquinol-4-one (2 mmol) and benzenesulfonyl isocyanate (2.2 mmol) in acetonitrile (9 mL) and heat at reflux for 48 hours. Add methanol (5 mL) to quench the reaction. Evaporate in vacuo to obtain a residue. Chromatograph the residue on a column of silica gel to give the title compound.

Workup

  1. temperatureat reflux for 48 hours
  2. customAdd methanol (5 mL) to quench
  3. customthe reaction
  4. customEvaporate in vacuo
  5. customto obtain a residue

Sources & evidence

ORD record
ord-f257df69fd414b46bdddd8457a8cf9ea
Source dataset
uspto-grants-1997_11
Patent number
US05684017

Reaction notes

Loading…