反应详情

2.25 cm3 of a 2N solution of sodium hydroxide is added at ambient temperature to 450 mg of the product obtained in Example 43 dissolved in 10 cm3 of ethanol, then the mixture is left for 3 days. The solvents are evaporated under reduced pressure, the residue is taken up in water, 2.25 cm3 of hydrochloric acid 2M/1 is added. The precipitate formed is filtered, washed with water, dried under reduced pressure and 380 mg of expected product is obtained which is recrystallized from isopropanol. M.p.=185°-186° C.

1. customThe solvents are evaporated under reduced pressure
2. addition2.25 cm3 of hydrochloric acid 2M/1 is added
3. customThe precipitate formed
4. filtrationis filtered
5. washwashed with water
6. customdried under reduced pressure