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HRID 2292687作成日：2026年10月25日

m-Chloroperbenzoic acid → Ethyl 2-butyl-1-[[2'-carboxy-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylsulphinyl)-1H-imidazole-5-carboxylate

https://huagongshe.com/reaction/2292687

反応式

関与物質

役割名称HCID仕込み量
反応物m-Chloroperbenzoic acidHCID 70297—
反応物Ethyl 2-butyl-1-[[2'-(methoxycarbonyl)-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylthio)-1H-imidazole-5-carboxylateHCID 21479063—
生成物Ethyl 2-butyl-1-[[2'-carboxy-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylsulphinyl)-1H-imidazole-5-carboxylateHCID 21479009259.4%

反応手順

The operation is carried out as in Example 15 starting with 1.55 g of the product obtained in Example 21 using 213 mg of metachloroperbenzoic acid. 1.8 g of crude product is obtained which is chromatographed on silica (eluant: methylene chloride - acetone (7-3)). 1.5 g of desired product is obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05684028
出典データセットuspto-grants-1997_11
ORD IDord-9a53143639854370b20572afadc2b753
出典メモuspto-grants-1997_11