Toluene → Benzeneacetamide

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3.37 parts of N,N,N',N'-tetramethyldiaminomethane in 44 parts of methylbenzene was added dropwise a solution of 2.59 parts of acetylchloride in 26 parts of methylbenzene during 30 minutes at 20°-25° C. under nitrogen atmosphere. Upon completion, the reaction mixture was further stirred for 20 minutes. 10.21 Parts of compound 15 and 78 parts of methylbenzene were added to the previous mixture and stirred for 5 hours at 80° C. The reaction mixture was allowed to cool to 20° C., the precipitated product was filtered off and dried in vacuo at 40° C., yielding 11.66 parts (97.8%) of N-[(dimethylamino)methyl]2,6-dichloro-α-[2-nitrophenyl)amino]benzeneacetamide.

Provenance & Evidence