HCID 10782159, compound → HCID 10732494, compound

Participants

Reaction Steps

A solution of 205 mg (0.634 mmol) of 2-methyl-5-nitro-1-(phenylmethyl)-1H-indole-3-acetamide in 30 mL of 2:1 THF/EtOH was hydrogenated at 60 psi (4218 g/cm2) of hydrogen for 4 hours using 0.1 g of Pd/C as catalyst. The catalyst was filtered and the filtrate concentrated at reduced pressure. The residue was chromatographed on silica eluting with EtOAc and then 5% MeOH/EtOAc to give 52 mg (28% yield) of 5-amino-2-methyl-1-(phenylmethyl)-1H-indole-3-acetamide, mp, 175°-178° C.

Provenance & Evidence