Sodium Hydroxide → HCID 44365186, compound

HRID 2292805Notes

Reaction equation

HRID 2292805 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[C:9]([CH2:25][C:26]([NH2:28])=[O:27])=[C:10]([CH3:24])[N:11]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[CH:18]=1)C.[OH-].[Na+:31]>C(O)C>[Na+:31].[NH2:28][C:26](=[O:27])[CH2:25][C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[CH:15][C:7]=2[O:6][CH2:5][C:4]([O-:29])=[O:3])[N:11]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[CH:18]=2)[C:10]=1[CH3:24]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10549745HCID 10549745, compound

Product 1

HCID 44365186HCID 44365186, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 155 mg (0.39 mmol) of [[3-(2-amino-2-oxoethyl)-1-[(3-chlorophenyl)methyl]-2-methyl-1H-indol-4-yl]oxy]acetic acid ethyl ester and 4 mL of 1N NaOH in 10 mL of ethanol was heated 0.5 hours, allowed to cool and the precipitate filtered to give 140 mg (88% yield) of [[3-(2-amino-2-oxoethyl)-1-[(3-chlorophenyl)methyl]-2-methyl-1H-indol-4-yl]oxy]acetic acid sodium salt, mp, >250° C.

Workup

  1. temperaturewas heated 0.5 hours
  2. temperatureto cool
  3. filtrationthe precipitate filtered

Sources & evidence

ORD record
ord-50b93850f3d9421d8f8e4e8ccf7aed54
Source dataset
uspto-grants-1997_11
Patent number
US05684034

Reaction notes

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