Cesium carbonate → HCID 178526660, compound

Participants

Reaction Steps

The thiourea (7) (0.50 g, 1.6 mmole) was suspended in 10 mL of n-propanol and cesium carbonate (0.53 g, 1.6 mmole) was added. The yellow suspension was stirred at ambient temperature for approximately 30 minutes, when the color changed from yellow to orange. The mixture was heated at reflux for about 24 hours, and the solvent was then removed on a rotary evaporator. The residue was partitioned between 1M HCl and ethyl acetate and the aqueous phase was brought to a pH of 8-9 with 1N NaOH. The resulting yellow solid was collected by filtration, washed successively with water and hexane, and then air dried to provide 0.10 g (23%) of nitroclonidine (3).

Provenance & Evidence