Hydrochloric Acid → HCID 178526660, compound

Participants

Reaction Steps

The thiourea (7) (0.50 g, 1.6 mmole) was suspended in 10 mL of toluene and imidazole (0.16 g, 1.6 mmole) was then added. The yellow mixture was heated at reflux for approximately 24 hours, then cooled to ambient temperature and treated with 1M HCl. The aqueous phase was separated, the toluene phase was extracted with 1M HCl, and the combined aqueous phases were brought to pH 8-9 with 1N NaOH. The resulting yellow solid was collected by filtration, washed successively with water and hexane, and then air dried to provide 0.30 g (68%) of nitroclonidine contaminated by a trace of a higher Rf impurity by TLC.

Provenance & Evidence