Benzylamine → HCID 178526660, compound

Participants

Reaction Steps

The thiourea (7) (0.36 g, 1.1 mmole) was suspended in 10 mL of toluene and excess benzylamine (1 mL) was then added. The mixture was heated at reflux for approximately 4 hours, and the solvent was then removed on a rotary evaporator. The residue was partitioned between 1M HCl and ethyl acetate. The aqueous phase was brought to pH 8-9 with 1N NaOH. The resulting yellow solid was collected by filtration, washed successively with water and hexane, and then air dried to provide 0.05 g (15%) of nitroclonidine.

Provenance & Evidence