反应详情

7.56 g (50 mmole) of N-phenyl glycine and 54.87 g (1.19 mmole) of formic acid were transferred into a reaction vessel and 16.23 g (159 mol) of acetic anhydride was added dropwise over about 10 minutes while cooling and stirring. The reaction mixture was stirred for one hour at 0° C. and for two hours at room temperature. The resulting reaction mixture was concentrated under vacuum to obtain crude crystals. The crystals were recrystallized from ethanol-isopropyl ether to obtain 7.47 g of the title compound (yield 83.4%).

1. temperaturewhile cooling
2. stirringThe reaction mixture was stirred for one hour at 0° C. and for two hours at room temperature
3. customThe resulting reaction mixture
4. concentrationwas concentrated under vacuum
5. customto obtain crude crystals
6. customThe crystals were recrystallized from ethanol-isopropyl ether