Trifluoroacetic acid → O-[2-(4-Chlorophenoxy)propyl]hydroxylamine

Participants

Reaction Steps

10 g (4.13 mmol) of acetone O-[2-(4-chloro-phenoxy)-propyl]-oxime and 31 g of 30% strength aqueous trifluoroacetic acid solution were heated for 83/4 hours at 80° C. at a reduced pressure of 430 mbar, similarly to experiment 3b, 100 g of water being continuously added dropwise to the reaction mixture and a water/acetone mixture being distilled off. The working up similarly to 3b) gave 6.4 g of 2-(4-chlorophenoxy)-propoxyamine in this case. Yield: 76%.

Provenance & Evidence