Hydrochloric Acid → HCID 67716932, compound

Participants

Reaction Steps

Was prepared analogously to Example 1c) starting from 3-(R/S)-amino-1-(p-isopropylbenzyl)-2,3,4,5-tetrahydro-benzazepin-2-one and (R)-alpha-[[(4-nitrophenyl)sulfonyl]-oxy]-4-phenylbutyric acid ethyl ester (Helv. Chim. Acta 71 (2), 337, 1988). Flash chromatography (eluant: ethyl acetate/hexane: 1:4) yields the two pure diastereoisomeric forms which, after being dissolved in ethyl acetate/tetrahydrofuran, are each converted separately into the corresponding hydrochloride by treatment with 3 equivalents of 1N hydrochloric acid. Rf values of the free bases (eluant ethyl acetate/hexane):

Provenance & Evidence