4-Methylmorpholine → HCID 22878777, compound

Participants

Reaction Steps

The reaction of 15 g of 3-amino-1-(p-nitrobenzyl)-2,3,4,5-tetrahydro-benzazepin-2-one with 22.1 g of (R)-alpha-[[(4-nitrophenyl)sulfonyl]oxy]-4-cyclohexylbutyric acid ethyl ester and 6.45 ml N-methylmorpholine yields the two diastereoisomeric esters 3-(S)-[(1-(S)-ethoxycarbonyl-3-cyclohexyl-propyl)-amino]-1-(p-nitrobenzyl)-2,3,4,5-tetrahydro-benzazepin-2-one and 3-(R)-[(1-(S)-ethoxycarbonyl-3-cyclohexyl-propyl)-amino]-1-(p-nitrobenzyl)-2,3,4,5-tetrahydro-benzazepin-2-one. Rf values (eluant ethyl acetate/hexane 1:2) non-polar component 0.78, polar component 0.69.

Provenance & Evidence