Hydrazine → 6-(4-Chlorophenyl)-2,3-dihydropyridazin-3-one

Participants

Reaction Steps

Hydrazine (8.9 mL, 0.28 mol) was added to a suspension of 3-(4-chlorobenzoyl)propionic acid (30.0 g, 0.14 mol) in EtOH. The resulting mixture was heated to reflux for 1 hour, stirred at room temperature overnight and chilled with an ice bath. The title compound precipitated out of this mixture (23.85 g, 81%) as a yellow solid: mp 175°-176° C.

Provenance & Evidence