HCID 12471370, compound → HCID 21479651, compound

HRID 2292969Notes

Reaction equation

HRID 2292969 reaction equation
[C:1]1([C:7]2[CH2:8][CH:9]3[CH2:25][CH:24]=[CH:23][CH:10]3[N:11]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Pd].C(O)C>[C:1]1([C:7]2[CH2:8][CH:9]3[CH2:25][CH2:24][CH2:23][CH:10]3[N:11]([S:13]([C:16]3[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=3)(=[O:15])=[O:14])[N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 12471370HCID 12471370, compound

Product 1

HCID 21479651HCID 21479651, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A catalytic amount of palladium on carbon was added to a solution of 3-phenyl-1-(4-tolylsulfonyl)-4,4a,5,7a-tetrahydro-1H-cyclopenta[c]pyridazine (0.5 g) in ethanol. The suspension was placed in a Parr Shaker apparatus under a H2 atmosphere (40 PSI) and shaken for 3 hours. The mixture was filtered through celite and concentrated. The resulting residue was purified by recrystallization from ethyl acetate to give the title compound as a solid: mp 171°-176° C.

Workup

  1. filtrationThe mixture was filtered through celite and
  2. concentrationconcentrated
  3. customThe resulting residue was purified by recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-5b8a0a049e1b41a6b415ac81c76a8c1f
Source dataset
uspto-grants-1997_11
Patent number
US05684151

Reaction notes

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