4-Hydroxybiphenyl → HCID 22878842, compound

Participants

Reaction Steps

To a solution of p-phenylphenol (250 mg, 1.46 mmol) in acetone, 1 mL of 10N KOH was added followed by acetobromogalactose (1.8 g, 4.37 mmol). The reaction mixture was stirred overnight at room temperature. TLC analysis showed no starting material left. 10N KOH (1 mL) was added to complete deacetylation and the solution was again stirred overnight. After evaporation of acetone, the crude material was taken up in ethyl acetate and washed with 5×150 mL of water. Ethyl acetate was dried with MgSO4 and concentrated under reduced pressure to obtain a white solid which was further purified by column chromatography using 30% methanol/ethyl acetate; 1H NMR (CD3OD) δ3.56-3.91 (m, 6H), 4.89 (m, 1H), 7.15-7.57 (m,9H).

Provenance & Evidence