1,3-Dibromo-2-propanol → HCID 86751509, compound

Participants

Reaction Steps

24 g (0.128 mol) of cysteic acid is dissolved in 160 ml of water and 10.2 g (0.255 mol) of sodium hydroxide is added. After dissolution, 6.8 g (0.064) sodium carbonate is added, followed by 80 ml ethanol. While refluxing the solution, 16.8 g (0.077 mol) 1,3-dibromo-2-propanol is added gradually during a period of 4 hours, followed by refluxing overnight. An additional 16.8 g (0.077 mol) of 1,3-dibromo-2-propanol is added, followed by all-day reflux. The solution is distilled to remove solvents and the resulting solid which contains HPDC and other materials is recovered and triturated with methanol/water. The purified solid is triturated again with methanol only and stirred overnight to remove residual materials, followed by dissolution in 10 cc water. Adjustment of the solution pH to 3-5 precipitates out pure HPDC.

Provenance & Evidence