Dichloromethane → 2-Chloro-4-(3,4-dihydroisoquinolin-2(1h)-yl)quinazoline

Participants

Reaction Steps

10 g Of the compound(50.2 mM) prepared in Preparation 2-1, 70 ml of dichloromethane and 7.8 ml of triethylamine (56 mM) were mixed and 6.4 ml of 1,2,3,4-tetrahydroisoquinoline(50.2 mM) was dropwise added slowly while maintaining the reaction temperature below 10° C., which was stirred at room temperature for 2 hours. The reaction mixture was dried over anhydrous sodium sulfate and concentrated under a reduced pressure. The residue was crystallized to give 14.6 g of the title compound.

Provenance & Evidence