Methanesulfonate → HCID 88205690, compound

HRID 2293173Notes

Reaction equation

HRID 2293173 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[C:11]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[CH3:22])[N:10]=[C:9]2[N:23]1[CH2:32][CH2:31][C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]1[CH3:33].[CH3:34][S:35]([O-:38])(=[O:37])=[O:36]>ClCCl>[CH3:34][S:35]([OH:38])(=[O:37])=[O:36].[F:21][C:18]1[CH:19]=[CH:20][C:15]([NH:14][C:11]2[N:10]=[C:9]([N:23]3[CH2:32][CH2:31][C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]3[CH3:33])[C:8]3[C:13](=[C:4]([O:3][CH3:2])[CH:5]=[CH:6][CH:7]=3)[N:12]=2)=[C:16]([CH3:22])[CH:17]=1

Participants

4

Reactant 2

HCID 85257MethanesulfonateHCID 21476498HCID 21476498, compound

Product 1

HCID 88205690HCID 88205690, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 1.20 g of the compound(2.80 mM) prepared in Example 34 and 50 ml of dichloromethane, 0.2 ml of methane sulfonate(3.08 mM) was dropwise added. The resultant was stirred at room temperature for 30 minutes and Concentrated under a reduced pressure. The residue produced was crystallized by adding ethyl ether to give 1.32 g of the title compound.

Workup

  1. additionwas dropwise added
  2. concentrationConcentrated under a reduced pressure
  3. customThe residue produced
  4. customwas crystallized
  5. additionby adding ethyl ether

Sources & evidence

ORD record
ord-e3b36f94b094404c829d113e3c40379c
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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