Maleic Acid → HCID 23223199, compound

HRID 2293174Notes

Reaction equation

HRID 2293174 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].Cl.[CH3:10][O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]=1[N:20]=[C:19]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=1[CH3:30])[N:18]=[C:17]2[N:31]1[CH2:40][CH2:39][C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:32]1[CH3:41]>C(O)C>[C:1]([OH:8])(=[O:7])[CH:2]([CH2:3][C:4]([OH:6])=[O:5])[OH:11].[F:29][C:26]1[CH:27]=[CH:28][C:23]([NH:22][C:19]2[N:18]=[C:17]([N:31]3[CH2:40][CH2:39][C:38]4[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=4)[CH:32]3[CH3:41])[C:16]3[C:21](=[C:12]([O:11][CH3:10])[CH:13]=[CH:14][CH:15]=3)[N:20]=2)=[C:24]([CH3:30])[CH:25]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 21476498HCID 21476498, compound

Product 1

HCID 23223199HCID 23223199, compoundYield 158.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 0.27 g of maleic acid(2.33 mM) and 50 ml of ethanol, 1.20 g of the compound (2.80 mM) prepared in Example 34 was dropwise added. The resultant was stirred at room temperature for 12 hours and concentrated under a reduced pressure. The residue produced was crystallized by adding ethyl ether and ethyl acetate, to give 1.15 g of the title compound.

Workup

  1. additionwas dropwise added
  2. concentrationconcentrated under a reduced pressure
  3. customThe residue produced
  4. customwas crystallized
  5. additionby adding ethyl ether and ethyl acetate

Sources & evidence

ORD record
ord-1016831a9f5e40a484c646d4dc71c884
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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