Sodium Hydroxide → 4-[N-Methyl-N-(2-methylbenzoyl)amino]benzoic acid

HRID 2293206Notes

Reaction equation

HRID 2293206 reaction equation
[CH3:1][N:2]([C:12]1[CH:22]=[CH:21][C:15]([C:16]([O:18]CC)=[O:17])=[CH:14][CH:13]=1)[C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[OH-].[Na+]>CO>[CH3:1][N:2]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[CH:21][CH:22]=1)[C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21837173ethyl 4-[N-methyl-N-(2-methylbenzoyl)amino]benzoate

Product 1

HCID 218370254-[N-Methyl-N-(2-methylbenzoyl)amino]benzoic acidYield 67.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A sample of 1.51 g of sodium hydride (60% in oil) is washed with hexane under argon to remove the oil. To the washed sodium hydride is added 5 ml of N,N-dimethylformamide. To this mixture is added dropwise a solution of 8.69 g of ethyl 4-[(2-methylbenzoyl)amino]benzoate in 20 ml of N,N-dimethylformamide. The mixture is stirred at room temperature for 0.5 hour and then 5.23 g of methyl iodide is added. The mixture is stirred at room temperature for 16 hours. The mixture is diluted with water and extracted with dichloromethane. The extract is dried (Na2SO4), concentrated to reduce the volume and the solution filtered through a thin pad of hydrous magnesium silicate. The filtrate is concentrated in vacuo to give 11 g of an oil (1:1 mixture of product and N,N-dimethylformamide). The preceding product, ethyl 4-[N-methyl-N-(2-methylbenzoyl)amino]benzoate, (11 g) is dissolved in 30 ml of methanol and 25 ml of 2N NaOH added. The mixture is refluxed for 2 hours and the solovent removed. The residue is extracted with ether (discard) and the remaining residue dissolved in 50 ml of water. The basic solution is acidified with 2N citric acid and the solid filtered off and washed with water. The product is air dried to give 6.72 g of crystals, m.p. 187°-190° C.

Workup

  1. temperatureThe mixture is refluxed for 2 hours
  2. customthe solovent removed
  3. extractionThe residue is extracted with ether (discard)
  4. dissolutionthe remaining residue dissolved in 50 ml of water
  5. filtrationthe solid filtered off
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-a76380773a4f40d1a2b317890e5500c1
Source dataset
uspto-grants-1997_11
Patent number
US05686445

Reaction notes

Loading…