6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepine → N-[4-[(5,6-Dihydro-7H-pyrimido[5,4-d][1]benzazepin-7-yl)carbonyl]phenyl]-2,5-dichlorobenzamide

HRID 2293261Notes

Reaction equation

HRID 2293261 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=1)=[O:5].[N:21]1[C:31]2[C:30]3[CH:32]=[CH:33][CH:34]=[CH:35][C:29]=3[NH:28][CH2:27][CH2:26][C:25]=2[CH:24]=[N:23][CH:22]=1>N1C=CC=CC=1>[N:21]1[C:31]2[C:30]3[CH:32]=[CH:33][CH:34]=[CH:35][C:29]=3[N:28]([C:11]([C:10]3[CH:14]=[CH:15][C:7]([NH:6][C:4](=[O:5])[C:3]4[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:2]=4[Cl:1])=[CH:8][CH:9]=3)=[O:12])[CH2:27][CH2:26][C:25]=2[CH:24]=[N:23][CH:22]=1

Participants

4

Reactant 2

HCID 543969886,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepineHCID 545700794-[(2,5-Dichlorobenzoyl)amino]benzoyl chloride

Product 1

HCID 67625585N-[4-[(5,6-Dihydro-7H-pyrimido[5,4-d][1]benzazepin-7-yl)carbonyl]phenyl]-2,5-dichlorobenzamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

As described for Example 1, 5 mmol of 4-[(2,5-dichlorobenzoyl)amino]benzoyl chloride is reacted with 5mmol of 5,6-dihydro-7H-pyrimido-[5,4-d][1]benzazepine in pyridine to give the product as a solid.

Sources & evidence

ORD record
ord-276d55fbf09e4375b33fcc6e1c77ed5f
Source dataset
uspto-grants-1997_11
Patent number
US05686445

Reaction notes

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