Trifluoroacetic acid → HCID 21476635, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6.5 g of N,N-dibenzyl-4-[(cyclopentylidene)(3-fluoro-4-methylphenyl)methyl]benzenesulfonamide, prepared in Example 10, in ml of trifluoroacetic acid is heated for 10 hours at 60° C. The mixture is poured into iced water and extracted with dichloromethane. The organic phase is washed with sodium bicarbonate solution, dried over magnesium sulfate and evaporated under vacuum. The residue is chromatographed on silica gel in a dichloromethane/acetone mixture (95/5) to give 3 g of 4-[(cyclopentylidene)(3-fluoro-4-methylphenyl)methyl]benzenesulfonamide in the form of a semicrystalline oil.

Provenance & Evidence