Dimethylamine → HCID 15411270, compound

Participants

Reaction Conditions

Reaction Steps

4.5 g of 2-chloro-5-[(cyclopentylidene)(4-methylsulfonylphenyl)-methyl]pyridine, prepared in Example 6, and 50 ml of a 33% solution of dimethyl-amine in ethanol are placed in a 125 ml autoclave. The mixture is heated at 180° C. under pressure for 7 hours. After cooling, the solvent is evaporated off under vacuum and the residue is taken up with water and then extracted with dichloromethane. The organic phase is dried over magnesium sulfate and evaporated under vacuum. The resulting oil crystallizes from an ethyl ether/isopropyl ether mixture to give 2.8 g of 2-(dimethylamino)-5-[(cyclopentylidene)(4-methylsulfonylphenyl)methyl]pyridine in the form of crystals melting at 122°-123° C.

Provenance & Evidence