ethyl 4,6-dichloro-3-formyl-1H-indole-2-carboxylate → HCID 57108709, compound

Participants

Reaction Steps

A solution of tertbutoxycarbonylmethyltriphenylphosphorane (5.33 g) and ethyl 3-formyl-4,6-dichloroindole-2-carboxylate (3 g) in dioxanlacetonitrile (1;1; 60 ml) was stirred at 60° for 7 hours. The solvent was evaported under reduced pressure and the residual oil was purified by chromatography, eluting with cyclohexane and ethyl acetate 7/3, to obtain the title compound (2,73 g) tlc EA/CH: 3/7; Rf=0.35.

Provenance & Evidence