Benzaldehyde → HCID 178476711, compound

Participants

Reaction Steps

871 mg (5 mmol) of arginine, 530 mg (5 mmol) of benzaldehyde, 1.122 g (6 mmol) of N-benzylmaleimide and 25 drops of acetic acid were heated under reflux in 25 ml of methanol for 60 hours. After cooling the colourless precipitate was filtered off under suction and washed with ether. 1.367 g of (1RS,3SR,3aRS,6aSR)-5-benzyl-1-(3-guanidino-propyl)-4,6-dioxo-octahydro-3-phenyl-pyrrolo[3,4-c]-pyrrole-1-carboxylic acid acetate (54%) were isolated as a colourless powder. M.p.: from 195° C. decomposition. ISP-MS: 450.4 ([M+H]+, 100).

Provenance & Evidence