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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2293325Generated: November 2, 2026

Sodium Hydroxide → 1-(4-Methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acid

https://huagongshe.com/reaction/2293325

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantEthyl 1-(4-methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylateHCID 22222563—
SolventTetrahydrofuranHCID 8028—
Product1-(4-Methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acidHCID 22222572—

Reaction Steps

In the same manner as above, a solution of ethyl 1-(4-methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylate (b-2) (3.12 g, 6.63 mmole) in tetrahydrofuran (100 ml) was hydrolyzed with a 1N aqueous sodium hydroxide solution (13 ml) at room temperature for 3.5 hours to give 1-(4-methoxybenzyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acid (c-2': MP) (2.32 g, 79%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05686442
Source datasetuspto-grants-1997_11
ORD IDord-0cc62ed7389d44858280be1712d42b59
Source noteuspto-grants-1997_11