Sodium Hydroxide → HCID 18937768, compound

Participants

Reaction Steps

In the same manner as above, a solution of ethyl 1-(4-methoxybenzyl)-5-(5-methoxy-4-methyl-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylate (b-2) (288 mg, 0.638 mmole) in tetrahydrofuran (7 ml) was hydrolyzed with a 1N aqueous sodium hydroxide solution (1.3 ml) at room temperature for 4.5 hours to give 1-(4-methoxybenzyl)-5-(5-methoxy-4-methyl-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acid (c-2': MP) (256 mg, 94%).

Provenance & Evidence